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DESCRIPTION OF THE ETS METHOD
Epitope-type-specificity (ETS) EIA reveals the time point of infection
by comparison of antibody reactivity with tertiary vs. primary structure
of a parvovirus B19 protein (VP2). IgG antibodies for the tertiary structure
of this protein are maintained through life in contrast to antibodies for
the primary structure, which are confined to the acute phase and early
convalescence after infection (#3). We have recently
identified an immunodominant epitope of 7 amino acids (heptapeptide) that
accounts for most of the acute-phase specificity of the ETS phenomenon,
and have set up a 2nd-generation ETS EIA for improved diagnosis of infections
by human parvovirus B19 (#1).
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